CRO

In a world where productivity means higher throughput, all laboratories would like to work with a technology providing an analysis 10 to 100 times faster than their current LC-MS/MS system.  Drug quantification in plasma sample can be as fast as 4 seconds per sample without compromising your accuracy.

You want to discover how... view how the LDTD performed for drugs quantification

Application notes

• AN-0706 High Throughput Analysis of 960 reserpine Samples in 1.9 Hours.

• AN-0708 LDTD-MS/MS in 1.8 seconds with RSD of 2.4 % : Paracetamol in Human Plasma Crash.

• AN-0709 Midazolam and 1-Hydroxymidazolam in Human Plasma : LDTD-MS/MS Analysis in 8 Seconds.

• AN-0710 LDTD-MS/MS Analysis in 9 seconds : Quantification of Mifepristone in Mouse Plasma.

• AN-0714 High Throughput LDTD-MS/MS IC₅₀ Determination of CYP Inhibition in HLM. 

Posters

• ASMS 2009  24 High throughput LDTD-MS/MS IC50 Determination of CYP Inhibition in Human Liver Microsomes (HLM).
• ASMS 2009 High Throughput Workflow for Midazolam and 1-Hydroxymidazolam Analysis in Human Plasma.
• ASMS 2008 Midazolam and 1-Hydroxymidazolam Determination in Human EDTA Plasma by LDTD/MS/MS in 8 seconds.
• ASMS 2008 High-Throughput Analysis of Mifepristone and Two Mifepristone Analogues in Mouse Heparin Plasma by LDTD-MS/MS in 9 seconds.
• ASMS 2007 High-Throughput LDTD-MS/MS Determination of Reserpine : 1000 Samples in less than 2 hours.

Posters produced by LDTD users

• IMSC 2009 Laser Diode Thermal Desorption (LDTD) Mass Spectrometry for High Throughput Analyses of Discovery DMPK In Vitro and In Vivo samples.
• ASMS 2009 Validation of Pioglitazone in Human Serum by Two Sample Introduction Methods : LDTD-APCI/MS/MS and LC-ESI/MS/MS.
• ASMS 2009 Application of LDTD-APCI-MS to Support Plasma Protein Binding Study in Drug Discovery.

Posters produced in collaboration with LDTD users 

• ASMS 2009 Analysis of Fatty Acid Methyl Esters Using the High Throughput LDTD Source Coupled to the LTQ Orbitrap Mass Spectrometer.
• ASMS 2008 Selected Ion Monitoring (SIM) Mode Data Collection Using the Laser Diode Thermal Desorption (LDTD) Source to Increase Sensitivity.
• ASMS 2008 Comparison of Laser Diode Thermal Desorption (LDTD) source vs LC-MS for the analysis of a therapeutic drug in biological extracts.

• ISSX 2008 Comparison of Various High Throughput Mass Spectrometry-based Technologies to Assess CYP Inhibitions.

• ASMS 2007 Application of a Laser Diode Thermal Desorption (LDTD) Ion Source for Mass Spectrometry in a Drug Discovery Environment.

Scientific Publication

• Analytical Chemistry 2007, 79(12), pp 4657-4665  High-throughput Cytochrome P450 Inhibition Assays Using Laser Diode Thermal Desorption-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry, Jin Wu, Christopher S. Hughes, Pierre Picard, Sylvain Letarte, Mireille Gaudreault, Jean-François Lévesque, Deborah A. Nicoll-Griffith, and Kevin P. Bateman DOI: 10.1021/ac070221o

NOTE

• The results published were obtained with a beta-LDTD ion source. Therefore, the laser patern reported should not be used with the current LDTD ion source. Moreover the CYP 1A2 should be run in negative mode. Please refer to the application note 0714 for updated operating conditions.