The LDTD source contains an infrared laser diode with an X-Y positioning system capable of holding one 96-well plate, a piston, a glass transfer tube, and a corona discharge needle. Upon operation, the plunger, powered by compressed air, is inserted into a sample well, the programmable laser thermally desorbs the dried sample (2 to 10 µL spotted) by heating the back of the plate, and the desorbed neutral sample is carried away by a carrier gas (air) through the transfer tube to the corona discharge region to be ionized and then introduced into the MS.
This technology operates using a specially designed 96-well plate, called LazWellTM.